Publications

Rahaman MM, Nguyen AT, Miller MP, Hahn SA, Sparacino-Watkins C, Jobbagy S, Carew NT, Cantu-Medellin N, Wood KC, Baty CJ, Schopfer FJ, Kelley EE, Gladwin MT, Martin E, Straub AC.  Cytochrome b5 reductase 3 modulates soluble guanylate cyclase redox state and cGMP signaling. Circulation Research, 2017 Jul 7; 121(2):137-148.

Shankman LS, Gomez D, Cherepanova OA, Salmon M, Alenca GF, Haskins RM, Swiatlowska P, Newman AC, Greene ES, Straub AC, Isakson BE, Randolph GJ, Owens GK.  KLF4 Dependent Phenotypic Modulation of SMCs Play a Key Role in Atherosclerotic Plaque Pathogenesis.  Nature Medicine 2015: 21(6): 628-37.

Rahaman MM, Reinders FG, Koes D, Nguyen AT, Mutchler SM, Sparacino-Watkins C, Alvarez RA, Miller MP, Cheng D, Chen BB, Jackson EK, Camacho CJ, Straub AC.  Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 that Increase Nitric Oxide Bioavalibility.  J Biol Chem. 2015 3;290(27):16861-72.

Straub AC, Butchner JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best, AK, Miller MP, Palmer LA, Columbus L, Somlyo AV, Le, TH, Isakson BE.  Hemoglobin α/ eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.  Arterioscler Thromb Vasc Biol 34:2594-2600, 2014.

Straub AC, AW Lohman, M Billaud, SR Johnstone, MY Lee, P Schoppee-Bortz, AK Best, ST Dwyer, L Columbus, B Gaston and BE Isakson.  Endothelial cell expression of hemoglobin alpha regulates nitric oxide signaling.  Nature 491:473-477, 2012.

Straub AC, M Billaud, SR Johnstone, AK Best, S Yemen, ST Dwyer, R Looft-Wilson, JJ Lysiak, B Gaston, LA Palmer and BE Isakson.  Compartmentalized connexin 43 S-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall.  Arterioscler Thromb Vasc Biol 31:399-407, 2011.

Billaud M, AW Lohman, AC Straub, R Looft-Wilson, SR Johnstone, CA Araj, AK Best, F Chekeni, K Ravichandran, S Penuela, D Laird and BE Isakson.  Pannexin 1 regulates alpha 1-adrenergic receptor-mediated vasoconstriction.  Circ Res 109:80-85, 2011.

Heberlein K, AC Straub, AK Best, RC Looft-Wilson and BE Isakson.  Plasminogen activator inhibitor-1 can regulate myoendothelial junction formation.  Circ Res 106:1092-1102, 2010.

Straub AC, KA Clark, MA Ross, AG Chandra, S Li, X Gao, PJ Pagano, DB Stolz and A Barchowsky.  Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH-oxidase generated superoxide.  J Clin Invest 118:3980-3989, 2008.

Straub AC, DB Stolz, MA Ross, A Hernandez-Zavala, NV Soucy, LR Klei and A Barchowsky.  Arsenic stimulates sinusoidal endothelial  cell capillarization and vessel remodeling in mouse liver.  Hepatology 45:205-212, 2007.