The Straub lab is devoted to understanding the basic mechanisms of redox regulation in the cardiovascular system. Our studies are conducted by a team of talented and dedicated investigators to define the role cytochrome b5 reductase 3 plays in nitric oxide signaling, heme iron redox control, lipid regulation, and metabolism.  We use of state-of the-art biochemical, genetic and pharmacological approaches understand the importance of this enzyme in endothelial cells, smooth muscle cells, cardiomyocytes and hematopoietic cells in physiology and disease. To see up-to-date listings of discoveries and publications from our lab please visit

Redox mechanisms governing microvascular tone

Solutions to improve microvascular health in cardiovascular disease

Uncovering new pathways regulating cardiomyocyte function

Computational guided screening of small molecules and peptidomimetics