Projects

The Straub lab is devoted to understanding the basic mechanisms of redox regulation in the cardiovascular system. Our studies are conducted by a team of talented and dedicated investigators to define the role cytochrome b5 reductase 3 plays in nitric oxide signaling, heme iron redox control, lipid regulation, and metabolism.  We use of state-of the-art biochemical, genetic and pharmacological approaches understand the importance of this enzyme in endothelial cells, smooth muscle cells, cardiomyocytes and hematopoietic cells in physiology and disease. To see up-to-date listings of discoveries and publications from our lab please visit www.ncbi.nlm.nih.gov/pubmed/?term=straub+ac.